INTERACTIVE ROLE OF SLEEP AND AROUSAL ON COGNITION AND BRAIN STRUCTURE IN CHRONIC PAIN PATIENTS

Abstract Chronic widespread pain (CWP) patients experience heightened arousal, insomnia complaints, poor cognition, and diffuse brain structure alterations, but interactive relationships among symptoms remain unexplored. We assessed whether physiological arousal [assessed via heart rate variability (HRV)] moderated associations between sleep and cognition/brain structure. Adults (N=42, Mage=46.2±13.7) with CWP and insomnia (difficulty falling/staying asleep) completed 14 daily sleep diaries, 5-minute Holter monitoring [HRV root mean square of successive normal heartbeats (RMSSD), low frequency/high frequency (lf/hf) computed], cognitive tasks [Stroop (processing speed/attention/inhibition), Sternberg (working memory)], and magnetic resonance imaging. Moderation analyses examined interactive associations between sleep [total sleep time (TST), wake after sleep onset, sleep onset latency (SOL)] and HRV with cognition/gray matter volume of frontal/temporal regions. SOL and lf/hf interacted in associations with working memory and attention/processing speed. Longer SOL was associated with worse Sternberg/Stroop at lowest sympathetic predominance levels. Conversely, longer SOL was associated with better Stroop at highest lf/hf. SOL and RMSSD interacted in associations with anterior cingulate, showing longer SOL associated with lower volumes at lowest arousal levels. TST and RMSSD interacted in associations with right hippocampus, with shorter TST associated with lower volume at highest/average arousal levels. Shared dynamic physiological arousal and sleep onset hyperarousal mechanisms impact cognition and neural structure in CWP. Longer SOL may only negatively impact cognition/anterior cingulate structure up to a certain arousal threshold, with shared mechanisms potentially benefitting cognition at highest arousal levels. At higher arousal, longer TST may protect against hippocampal volume reduction. Future prospective studies are needed to inform temporal characteristics.


POOR SLEEP HEALTH MAY BUILD THE ONSET OF A FEAR OF FALLING AMONG COMMUNITY-DWELLING OLDER ADULTS
Tuo-Yu Chen 1 , Soomi Lee 2 , Kai-Wen Hsu 1 , and Orfeu Buxton 3 , 1. Taipei Medical University, Taipei, Taipei, Taiwan (Republic of China) A greater fear of falling (FOF) predicts activity restrictions, falls, disability, and increases the risk of mortality among older adults.Although poor sleep has been identified as a relevant factor for FOF among older adults, evidence is primarily shown in cross-sectional studies using isolated sleep characteristics.Whether multidimensional sleep health contributes to increase in FOF among older adults who are particularly vulnerable to falls is less well understood.We investigated the longitudinal relationship between sleep health and the incidence of FOF among community-dwelling older adults and how the association differed between those with or without prior falls experiences.Data were from individuals who completed the sleep module in the National Health andAging Trends Study (2013-2014;n=695

TECHNOLOGY-BASED ASSESSMENT OF EMOTIONS AND SOCIAL BEHAVIORS IN OLDER ADULTS' AND COUPLES' HOMES
Chair: Kuan-Hua Chen Discussant: Robert Levenson As people age, emotions and close social interactions are increasingly important because our social circle tends to shrink.Research on social and emotional aging typically relies on questionnaires and laboratory assessments.However, most emotions and social behaviors occur in naturalistic and interpersonal contexts.Advances in modern technologies, including telecommunications, mobile or embedded devices and sensors, provide researchers with exciting opportunities for naturalistic, long-term, objective, and timely assessment of emotions and social behaviors outside of the lab.Increased accessibility of technologies further allows community-based, large-scale assessment.The proposed symposium highlights recent advances in-home assessment of emotions and social behaviors from four different institutions that leverage various active (e.g., ecological momentary assessment, portable lab) and passive (i.e., motion and door sensors, wearables) technologies to assess multiple aspects of emotions and social behaviors (e.g., physiological responses, emotional experience, behaviors and interpersonal behavioral synchrony, apathy, agitation) in healthy and clinical aging.Four presentations covering four different exemplary studies will be given by researchers at different career stages with diverse ethnic/cultural and training backgrounds (e.g., mechanical engineering, psychology, neuroscience).An integrated discussion will be given by a senior researcher and leading expert in the area.Together, the symposium will provide the general audience with an overview of recent advances in in-home assessment technologies.This symposium will also launch communication and collaborations between researchers from different disciplines who use (or plan to adopt) contemporary technologies to conduct research in naturalistic settings to promote a better understanding of human social and emotional aging.

REMOTE ASSESSMENTS OF EMOTIONAL FUNCTIONING FOR INDIVIDUALS WITH DEMENTIA AND THEIR CAREGIVERS
Casey Brown 1 , Kuan-Hua Chen 2 , Julian Scheffer 2 , Deepak Paul 2 , and Robert Levenson 2 , 1. Georgetown University, Washington, District of Columbia, United States, 2. University of California, Berkeley, Berkeley, California, United States Emotional impairments are a common symptom of neurodegenerative disorders that can be devastating for persons with the dementia (PWDs) and family members who provide care (i.e., caregivers).Emotional functioning can be well characterized and quantified using laboratory assessments of behavioral, physiological, and self-reported responses to emotional stimuli.However, continuous declines in functioning make it especially difficult for PWDs and caregivers to visit a research laboratory repeatedly over time.In order to understand changes in emotional functioning across time and their impact on PWDs and caregivers longitudinally, there is a need for technology to support remote assessments of emotional functioning.We developed a portable version of laboratory assessments-Laboratory in a Suitcase Assessment (LISA)-to collect data from PWDs and their caregivers remotely in their homes.In a shippable suitcase, LISA provides the necessary equipment for: (a) presenting emotional stimuli via laptop screen and headphones; (b) obtaining audio and video recordings of participants' behavior; (c) obtaining continuous ratings of emotional experience via a rating dial; (d) measuring cardiovascular, electrodermal, and somatic responses from PWDs and caregivers via wearable devices; (e) synchronizing behavior and physiology; and (f) maintaining two-way communication with participants via Zoom.We present high quality physiological, behavioral, and self-report data collected using LISA with 17 PWD-caregiver dyads.Data collected with LISA are comparable to data collected in the laboratory, indicating that LISA could enable researchers to continue data collection further into the course of disease when travel to in-person laboratory sessions would no longer be feasible.

THINKING ABOUT TIME INFLUENCES EMOTIONAL EXPERIENCE DIFFERENTLY IN OLDER AND YOUNGER ADULTS
Enna Chen 1 , Claire Growney 1 , and Laura Carstensen 2 , 1. Stanford University,Stanford,California,United States,2. Stanford,Stanford,California,United States According to socioemotional selectivity theory (SST), as future time horizons shorten with age, people come to prioritize present-oriented, emotionally meaningful goals.SST posits that present orientation contributes to emotional well-being.Using experience sampling, the present study examined (1) age differences in momentary time orientations, (2) associations between momentary time orientations and emotional well-being, and (3) age moderation of these associations.A sample of 190 people, aged 18 to 94 years, participated in an ecological momentary assessment study where they simultaneously reported time orientations and experienced emotions at five randomly selected times every day for seven days. .We found that age was not associated with time orientation.However, on occasions when

INTERACTIVE ROLE OF SLEEP AND AROUSAL ON COGNITION AND BRAIN STRUCTURE IN CHRONIC PAIN PATIENTS Ashley Curtis 1 , Neetu Nair 2 , Jason Craggs 1 ,
). FOF was assessed with a single item.Multidimensional sleep health was measured with self-reported sleep items based on the SATED model (i.e., sleep satisfaction, daytime alertness, timing, efficiency, and duration).Covariates included sociodemographics, assistive device usage, health, and sleep medications.Multiple logistic regression was used to analyze the data.Poor sleep health was associated with the onset , sleep onset latency (SOL)] and HRV with cognition/gray matter volume of frontal/temporal regions.SOL and lf/hf interacted in associations with working memory and attention/processing speed.Longer SOL was associated with worse Sternberg/Stroop at lowest sympathetic predominance levels.Conversely, longer SOL was associated with better Stroop at highest lf/hf.SOL and RMSSD interacted in associations with anterior cingulate, showing longer SOL associated with lower volumes at lowest arousal levels.TST and RMSSD interacted in associations with right hippocampus, with shorter TST associated with lower volume at highest/average arousal levels.Shared dynamic physiological arousal and sleep onset hyperarousal mechanisms impact cognition and neural structure in CWP.Longer SOL may only negatively impact cognition/anterior cingulate structure up to a certain arousal threshold, with shared mechanisms potentially benefitting cognition at highest arousal levels.At higher arousal, longer TST may protect against hippocampal volume reduction.Future prospective studies are needed to inform temporal characteristics.